This time around, Ratchet and Clank are on a mission trying to locate several famous heroes who have mysteriously disappeared. The good news is the duo located the missing people. The bad news is they find them after getting captured by the same person who has been going around stealing heroes. It turns out that a crazed media mogul named Gleeman Vox has been gathering heroes to act as contestants on his ultra-violent combat reality show, "DreadZone." Vox soon realizes that Ratchet has champion potential, so he forces the furry little guy into battle. Now, encased in a suit of armor and sporting an explosive collar to keep him in line, Ratchet has to compete in the game and go up against the deadly Exterminators (a team of warriors lead by a man called Ace Hardlight) in order to save himself and his friends.